Cancer-killing T cells have been programmed to have two levels of specificity. First, the T cells have been equipped with a receptor sensitive to a protein that is found only in central nervous system ...

Cells can die naturally from age or disease, but organisms can also actively trigger the death of certain cells when needed. This is known as programmed cell death (PCD), a central biological system ...

Metacaspases, ancestral homologues of the caspase family, are pivotal cysteine proteases found in a wide range of unicellular organisms, including yeasts, algae, and phytoplankton. These enzymes ...

New basic science insights into programmed cell death could offer relief for inflammatory bowel disease. Many people with IBD, an umbrella term that includes ulcerative colitis and Crohn's disease, ...

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

Cells have the remarkable ability to initiate their own death through a mechanism called programmed cell death, also known as apoptosis. Apoptosis contains sophisticated signalling pathways and ...

Researchers at UT Southwestern Medical Center have identified a protein that causes human cell membranes to break open in a form of inflammatory programmed cell death called necroptosis. Their ...

This finding, he suggests, helps link the study of cell death in the worm and oncogenesis in people. "There were a number of papers that had suggested a relationship between cell death and oncogenesis ...

This paper explores the potential of mitochondrial-associated programmed-cell-death (mtPCD) patterns as biomarkers for predicting the prognosis of non-small-cell lung cancer (NSCLC). NSCLC is the most ...

Different types of programmed cell death. This picture summarizes the different pathways of programmed cell death (Note: ROS: reactive oxygen species). By unveiling the complex interactions between ...

The development of humans and other animals unfolds gradually over time, with cells taking on specific roles and functions ...