When researchers verify the effects of genes or gene–environment interactions on common diseases or age-related diseases, such as diabetes, cancer, or coronary heart disease, they usually regard age ...
A hybrid method that combines Laplace's approximation and Monte Carlo simulations to evaluate integrals in the likelihood function is proposed for estimation of the parameters in nonlinear mixed ...
The ACCENT database, with individual patient data for 20 898 patients from 18 colon cancer clinical trials, was used to support Food and Drug Administration (FDA) approval of 3-year disease-free ...
In this article, we estimate heritability or intraclass correlation in a mixed linear model having two sources of variation. In most applications, the commonly used restricted maximum likelihood (REML ...
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