CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...
R-loops are three-stranded nucleic acid structures that are abundant and widespread across the genome and that have important physiological roles in many nuclear processes. Their accumulation is ...
In the early 2000s, Tawfik presented his ‘New View’ on enzyme evolution, highlighting the role of conformational plasticity in expanding the functional diversity of limited repertoires of sequences.