The endoderm layer destined to be primitive gut is a mosaic of earlier visceral endoderm and definitive endoderm that arises later, during gastrulation. Live imaging now reveals that in mouse embryos, ...

The liver and pancreas both arise from a multipotent population of endoderm cells and share many characteristics of their early development, including the expression of common regulatory transcription ...

Pluripotent stem cells, created from human skin or mouse ear tissue, are shown here becoming endoderm cells. The endoderm is one of the three primary germ layers that ultimately contribute to the ...

Scientists revise the current textbook knowledge about gastrulation, the formation of the basic body plan during embryonic development. Their study in mice has implications for cell replacement ...

Diabetes. 2013;62(10):3514-3522. In summary, our data do not support an early phase of endocrine differentiation in human embryos analogous to primary transition during mouse development, and we did ...

An unexpectedly versatile and regenerative stem cell in early embryos may be key to creating new effective fertility treatments, suggests a new study in mice from the University of Copenhagen. It ...

Summary Scientists in the Sloan Kettering Institute have combined powerful laboratory and computational techniques to analyze the earliest moments of mouse development. The results could help explain ...

How do cells turn into organs? During embryonic development, three germ layers form, known as the endoderm, the mesoderm, and the ectoderm. These germ layers give rise to different parts of the ...

Molecular gradients have been established as a key driving force for cellular organization in the formation of early structures during embryonic development. A new live imaging technique has been ...