Conventional studies on stem cell fates are primarily focused on transcription factors, with the limited consideration for 3D genome architecture. The cohesin complex dynamically restructures ...

A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept, the ...

Our skin and mucous membranes are protected by epithelial cells. This 'barrier' tissue performs its function thanks to specialized structures called 'junctions'. They ensure cell cohesion and regulate ...

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...